CB2R PAM
CB2R PAM is an orally active cannabinoid type-2 receptors (CB2Rs) positive allosteric modulator. CB2R PAM displays antinociceptive activity in vivo in an experimental mouse model of neuropathic pain[1].
Product Specifications
CAS Number
[2244579-87-9]
UNSPSC
12352005
Target
Cannabinoid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cb2r-pam.html
Concentration
10mM
Purity
98.09
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
FC1=CC=C(CN2C(C(NC(C3CCCCCC3)=O)=C(C)C(Br)=C2)=O)C=C1
Molecular Formula
C21H24BrFN2O2
Molecular Weight
435.33
References & Citations
[1]Gado F, et al. Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief. J Med Chem. 2019;62 (1) :276-287.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CB2
Available Sizes
Curated Selection
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