IA9 (TFA)

IA9 TFA (human TREM-2 182-190 TFA) is a potent, CNS-penetrant TREM-2 inhibitor. IA9 TFA can diminish the release of proinflammatory cytokines and suppress joint inflammation and damage in a Collagen (HY-P5003) -induced arthritis (CIA) mouse model. IA9 TFA can be used for neuroinflammation PET imaging. IA9 TFA can be used for Rheumatoid arthritis (RA) and neuroinflammation research[1][2].

Product Specifications

Product Name Alternative

Human TREM-2 182-190 (TFA)

UNSPSC

12352209

Target

TREM receptor

Type

Peptides

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ia9-tfa.html

Purity

98.90

Solubility

DMSO : 6.25 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@@H](C)CC)N.O=C(C(F)(F)F)O.[x]

Molecular Formula

C51H88N10O10.xC2HF3O2

Molecular Weight

1001.31 (free acid)

References & Citations

[1]Sigalov AB. Inhibition of TREM-2 Markedly Suppresses Joint Inflammation and Damage in Experimental Arthritis. Int J Mol Sci. 2022;23 (16) :8857. Published 2022 Aug 9.|[2]Zonghua Luo, et al. Development of a Ga-68 Labeled Peptide Tracer Targeting TREM2 for Neuroinflammation PET Imaging. Journal of Nuclear Medicine. Jun 2025, 66 (supplement 1) 251786.