Thalidomide-5-CH2-NH2 (hydrochloride)

Thalidomide-5-CH2-NH2 (hydrochloride) is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-CH2-NH2 (hydrochloride) can be connected to the ligand for protein by a linker to form PROTACs[1].

Product Specifications

CAS Number

[1010100-22-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thalidomide-5-ch2-nh2-hydrochloride.html

Purity

98.55

Solubility

10 mM in DMSO

Smiles

NCC1=CC(C(N(C2C(NC(CC2)=O)=O)C3=O)=O)=C3C=C1.Cl

Molecular Formula

C14H14ClN3O4

Molecular Weight

323.73

Precautions

H302, H315, H319, H335

References & Citations

[1]Makbul C, Nassal M, Böttcher B. Slowly folding surface extension in the prototypic avian hepatitis B virus capsid governs stability. Elife. 2020;9:e57277. Published 2020 Aug 14.|[2]Sato T, Ito T, Handa H. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.