KH7
KH7 is a soluble adenylyl cyclase (sAC) -specific inhibitor, with IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays[1]. KH7 is also a cAMP inhibitor[2].
Product Specifications
CAS Number
330676-02-3
UNSPSC
12352005
Hazard Statement
H301
Target
Adenylate Cyclase
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/KH7.html
Concentration
10mM
Purity
99.0
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
CC(SC1=NC2=CC=CC=C2N1)C(N/N=C/C3=CC(Br)=CC=C3O)=O
Molecular Formula
C17H15BrN4O2S
Molecular Weight
419.30
Precautions
H301
References & Citations
[1]Hess KC, et al. The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Dev Cell. 2005 Aug;9 (2) :249-59.|[2]Han J, et al. Maresin Conjugates in Tissue Regeneration 1 improves alveolar fluid clearance by up-regulating alveolar ENaC, Na, K-ATPase in lipopolysaccharide-induced acute lung injury. 4.658J Cell Mol Med. 2020 Mar 11.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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