KH7

KH7 is a soluble adenylyl cyclase (sAC) -specific inhibitor, with IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays[1]. KH7 is also a cAMP inhibitor[2].

Product Specifications

CAS Number

[330676-02-3]

UNSPSC

12352005

Hazard Statement

H301

Target

Adenylate Cyclase

Type

Reference compound

Related Pathways

GPCR/G Protein

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/KH7.html

Concentration

10mM

Purity

99.0

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

CC(SC1=NC2=CC=CC=C2N1)C(N/N=C/C3=CC(Br)=CC=C3O)=O

Molecular Formula

C17H15BrN4O2S

Molecular Weight

419.30

Precautions

H301

References & Citations

[1]Hess KC, et al. The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Dev Cell. 2005 Aug;9 (2) :249-59.|[2]Han J, et al. Maresin Conjugates in Tissue Regeneration 1 improves alveolar fluid clearance by up-regulating alveolar ENaC, Na, K-ATPase in lipopolysaccharide-induced acute lung injury. 4.658J Cell Mol Med. 2020 Mar 11.