IL Receptor, CXCR Antibody

Anti-CXCL8/IL-8 Antibody is a humanized monoclonal antibody targeting the chemokine CXCL8 (Interleukin-8, IL-8) . CXCL8 is a pro-inflammatory chemokine frequently overexpressed in the tumor microenvironment, which promotes tumor angiogenesis, survival, proliferation, and migration by binding to its G protein-coupled receptors, CXCR1 and CXCR2. This antibody effectively neutralizes extracellular CXCL8, blocking its interaction with CXCR1/2 and subsequently disrupting the paracrine and autocrine signaling loops driven by CXCL8. This mechanism inhibits tumor-associated vascularization and diminishes tumor cell resistance to conventional therapies, making it a critical tool for researching solid tumor progression, metastasis, and microenvironmental modulation.