Others Antibody
Anti-PCSK9 Antibody is a humanized monoclonal antibody targeting Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) . PCSK9 is a serine protease primarily secreted by the liver that binds to the Low-Density Lipoprotein Receptor (LDLR) on the hepatocyte surface, promoting its internalization and lysosomal degradation, thereby preventing LDLR recycling to the cell surface. This reduces the liver's ability to clear LDL-cholesterol (LDL-C) from the blood. Anti-PCSK9 Antibody specifically binds to PCSK9, blocking its interaction with LDLR and inhibiting PCSK9-mediated LDLR degradation. This action increases the density of LDLR on hepatocytes, enhances LDL-C clearance, and significantly lowers serum cholesterol levels. It is widely used in research on hypercholesterolemia and atherosclerotic cardiovascular diseases.
Product Specifications
Target
Others
Clonality
Monoclonal
Conjugation
Unconjugated
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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