Immunology/Inflammation related Antibody
PF-5212374 (TRU-015) is a CD20-directed small modular immunopharmaceutical (SMIP) . Unlike traditional full-length antibodies, TRU-015 is a dimeric fusion protein comprising a single-chain Fv (scFv) binding domain coupled to the hinge and Fc regions of IgG1. It specifically binds to CD20 on the surface of B cells, activating Immunology/Inflammation-related signaling pathways to effectively mediate antibody-dependent cellular cytotoxicity (ADCC) and direct induction of apoptosis, resulting in the depletion of both normal and malignant B cells.
Product Specifications
Target
Immunology/Inflammation related
Conjugation
Unconjugated
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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