Immunology/Inflammation related Antibody

PF-5212374 (TRU-015) is a CD20-directed small modular immunopharmaceutical (SMIP) . Unlike traditional full-length antibodies, TRU-015 is a dimeric fusion protein comprising a single-chain Fv (scFv) binding domain coupled to the hinge and Fc regions of IgG1. It specifically binds to CD20 on the surface of B cells, activating Immunology/Inflammation-related signaling pathways to effectively mediate antibody-dependent cellular cytotoxicity (ADCC) and direct induction of apoptosis, resulting in the depletion of both normal and malignant B cells.