Binodenoson

Binodenoson (MRE-0470) is a potent and selective A2A adenosine receptor agonist (KD=270 nM) . Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stress imaging[1].

Product Specifications

CAS Number

[144348-08-3]

Product Name Alternative

MRE-0470; WRC 0470

UNSPSC

12352005

Hazard Statement

H302, H318

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/binodenoson.html

Purity

98.01

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

NC1=NC(N/N=C/C2CCCCC2)=NC3=C1N=CN3[C@H]4[C@H](O)[C@H](O)[C@@H](CO)O4

Molecular Formula

C17H25N7O4

Molecular Weight

391.42

Precautions

H302, H318

References & Citations

[1]Sullivan GW, et al. Neutrophil A2A adenosine receptor inhibits inflammation in a rat model of meningitis: synergy with the type IV phosphodiesterase inhibitor, rolipram. J Infect Dis. 1999;180 (5) :1550-1560.|[2]Glover DK, et al. Pharmacological stress thallium scintigraphy with 2-cyclohexylmethylidenehydrazinoadenosine (WRC-0470) . A novel, short-acting adenosine A2A receptor agonist. Circulation. 1996;94 (7) :1726-1732.