Binodenoson
Binodenoson (MRE-0470) is a potent and selective A2A adenosine receptor agonist (KD=270 nM) . Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stress imaging[1].
Product Specifications
CAS Number
144348-08-3
Product Name Alternative
MRE-0470; WRC 0470
UNSPSC
12352005
Hazard Statement
H302, H318
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/binodenoson.html
Purity
98.01
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
NC1=NC(N/N=C/C2CCCCC2)=NC3=C1N=CN3[C@H]4[C@H](O)[C@H](O)[C@@H](CO)O4
Molecular Formula
C17H25N7O4
Molecular Weight
391.42
Precautions
H302, H318
References & Citations
[1]Sullivan GW, et al. Neutrophil A2A adenosine receptor inhibits inflammation in a rat model of meningitis: synergy with the type IV phosphodiesterase inhibitor, rolipram. J Infect Dis. 1999;180 (5) :1550-1560.|[2]Glover DK, et al. Pharmacological stress thallium scintigraphy with 2-cyclohexylmethylidenehydrazinoadenosine (WRC-0470) . A novel, short-acting adenosine A2A receptor agonist. Circulation. 1996;94 (7) :1726-1732.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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