(Rac) -TTA-P2

(Rac) -TTA-P2 is the isomer of TTA-P2 (HY-10035), and can be used as an experimental control. TTA-P2 (T-Type calcium channel inhibitor) is a potent inhibitor of T-Type calcium channel. TTA-P2 penetrates well the CNS and blocks the native T-type currents in deep cerebellar nuclear neurons, the window current is completely abolished both for wild-type and mutant Cav3.1 channels. TTA-P2 has the potential for the research of neurology disease[1].

Product Specifications

CAS Number

[918430-49-6]

Product Name Alternative

(Rac) -T-Type calcium channel inhibitor

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Calcium Channel; Drug Isomer

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rac-tta-p2.html

Purity

98.69

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C(NCC1(F)CCN(CC2CC(OCC2)(C)C)CC1)C3=CC(Cl)=CC(Cl)=C3

Molecular Formula

C21H29Cl2FN2O2

Molecular Weight

431.37

Precautions

H302, H315, H319, H335

References & Citations

[1]M R Hellberg, et al. Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist. J Ocul Pharmacol Ther. 2001 Oct;17 (5) :421-32.