CDK9-IN-8

CDK9-IN-8 is a highly effective and selective CDK9 inhibitor with an IC50 of 12 nM.

Product Specifications

CAS Number

[2105956-51-0]

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CDK9-IN-8.html

Purity

99.16

Solubility

DMSO : 5.2 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

FC1=CC=C(NC(C2(CC2)C(NC3=CC=C(NC4=NC=C5C(N(C6CCCC6)C(C(N(C)C)=O)=C5)=N4)C=C3)=O)=O)C=C1

Molecular Formula

C31H32FN7O3

Molecular Weight

569.63

References & Citations

[1]Li Y, et al. Discovery of a highly potent, selective and novel CDK9 inhibitor as an anticancer drug candidate. Bioorg Med Chem Lett. 2017 Aug 1;27 (15) :3231-3237.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK9

Available Sizes

Curated Selection

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