ATF4-IN-1
ATF4-IN-1 (Compound 21) is an ATF4 inhibitor and also an eIF2B activator. ATF4-IN-1 can be used in research on neurodegenerative diseases[1].
Product Specifications
CAS Number
[2991057-76-0]
UNSPSC
12352005
Target
Eukaryotic Initiation Factor (eIF)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/atf4-in-1.html
Purity
99.29
Solubility
DMSO : 6.25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N[C@H]1CC[C@H](C2=NN=C(C3=CC4=CC(Cl)=CC=C4O3)O2)CC1)COC5=CC=C(Cl)C=C5
Molecular Formula
C24H21Cl2N3O4
Molecular Weight
486.35
References & Citations
[1]Pei Y, et al. Design, Synthesis, and Biological Evaluation of Eukaryotic Initiation Factor 2B (eIF2B) Activators. ChemMedChem. 2024 Mar 1:e202300716.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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