Pyrithioxin (dihydrochloride) (Standard)

Pyrithioxin (Pyritinol) dihydrochloride (Standard) is the analytical standard of Pyrithioxin dihydrochloride (HY-B0910A) . Pyrithioxin (Pyritinol) is an orally active neurodynamic compound. Pyrithioxin can promote the metabolism of glucose and amino acids, increase carotid blood flow and improve cerebral blood flow. Pyrithioxin exhibits anti-inflammation, anti-tumor and neuroprotective effect. Pyrithioxin can be used for the researches of cancer, inflammation, immunology, metabolic and neurological disease such as cerebral infarct, epilepsy, fibrosarcomas and rheumatoid polyarthritis[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[10049-83-9]

Product Name Alternative

Pyritinol dihydrochloride (Standard) ; Pyridoxine disulfide dihydrochloride (Standard) ; Vitamin B6 disulfide dihydrochloride (Standard)

UNSPSC

12352005

Target

Drug Derivative; Reference Standards

Type

Reference Standards

Related Pathways

Others

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pyrithioxin-dihydrochloride-standard.html

Smiles

OCC1=C(CSSCC2=C(CO)C(O)=C(C)N=C2)C=NC(C)=C1O.[H]Cl.[H]Cl

Molecular Formula

C16H22Cl2N2O4S2

Molecular Weight

441.39

References & Citations

[1]Stoica E, et al. Facilitation through hyperventilation of therapeutic effect of pyrithioxin in cerebral infarct patients. Eur Neurol. 1975;13 (4) :285-303.|[2]von Metzler A. et al. [Antineoplastic activity of drugs affecting the central nervous system against chemically induced tumors in the rat (author's transl) ]. J Cancer Res Clin Oncol. 1979 Sep;95 (1) :11-8. German.|[3]Crouzet J, et al. Pyrithioxine et polyarthrite rhumatoïde [Pyrithioxin and rheumatoid polyarthritis]. Rev Rhum Mal Osteoartic. 1986 Jan;53 (1) :45-8.|[4]Marston HM, et al. Effects of the chronic administration of pyrithioxin on behaviour and cholinergic function in young and aged rats. J Psychopharmacol. 1987 Jan;1 (4) :237-43.|[5]Zheng S, et al. Combined mutagenesis and metabolic regulation to enhance D-arabitol production from Candida parapsilosis. J Ind Microbiol Biotechnol. 2020 May;47 (4-5) :425-435.|[6]Martínez-Lage JM, et al. Asociación de piritioxina y difenilhidantoina, en el tratamiento de los síndromes epilépticos orgánicos [Association of pyrithioxin and diphenylhydantoin in the treatment of organic epileptic syndromes]. Med Clin (Barc) . 1965 Sep;45 (3) :204-5.|[7]Jiménez-Andrade GY, et al. Pyritinol reduces nociception and oxidative stress in diabetic rats. Eur J Pharmacol. 2008 Aug 20;590 (1-3) :170-6.