(-) -Alkannin
(-) -Alkannin, found in Alkanna tinctoria, is used as a food coloring. (-) -Alkannin shows anticancer activity, arrests cell cycle, and induces apoptosis. (-) -Alkannin improves hepatic inflammation in a Rho-kinase pathway[1][2][3].
Product Specifications
CAS Number
517-88-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis
Type
Natural Products
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/alkannin.html
Concentration
10mM
Purity
99.88
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
OC1=C2C(C(C=C([C@H](C/C=C(C)/C)O)C2=O)=O)=C(O)C=C1
Molecular Formula
C16H16O5
Molecular Weight
288.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Hosokawa Y, et al. Alkannin inhibits CCL3 and CCL5 production in human periodontal ligament cells. Cell Biol Int. 2016 Dec;40 (12) :1380-1385.|[2]Huu Tung N, et al. Naphthoquinone components from Alkanna tinctoria (L.) Tausch show significant antiproliferative effects on human colorectal cancer cells. Phytother Res. 2013 Jan;27 (1) :66-70.|[3]Xue W, et al. Alkannin Inhibited Hepatic Inflammation in Diabetic Db/Db Mice. Cell Physiol Biochem. 2018;45 (6) :2461-2470.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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