(-) -Alkannin

(-) -Alkannin, found in Alkanna tinctoria, is used as a food coloring. (-) -Alkannin shows anticancer activity, arrests cell cycle, and induces apoptosis. (-) -Alkannin improves hepatic inflammation in a Rho-kinase pathway[1][2][3].

Product Specifications

CAS Number

[517-88-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis

Type

Natural Products

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/alkannin.html

Concentration

10mM

Purity

99.88

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

OC1=C2C(C(C=C([C@H](C/C=C(C)/C)O)C2=O)=O)=C(O)C=C1

Molecular Formula

C16H16O5

Molecular Weight

288.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Hosokawa Y, et al. Alkannin inhibits CCL3 and CCL5 production in human periodontal ligament cells. Cell Biol Int. 2016 Dec;40 (12) :1380-1385.|[2]Huu Tung N, et al. Naphthoquinone components from Alkanna tinctoria (L.) Tausch show significant antiproliferative effects on human colorectal cancer cells. Phytother Res. 2013 Jan;27 (1) :66-70.|[3]Xue W, et al. Alkannin Inhibited Hepatic Inflammation in Diabetic Db/Db Mice. Cell Physiol Biochem. 2018;45 (6) :2461-2470.