(Z) 2S,4R-Sacubitril

(Z) 2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.

Product Specifications

CAS Number

[2751722-77-5]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/_Z_2S,4R-Sacubitril.html

Purity

96.89

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

[H]N(C(/C=C\C(O)=O)=O)[C@H](CC(C=C1)=CC=C1C2=CC=CC=C2)C[C@@H](C)C(OCC)=O

Molecular Formula

C24H27NO5

Molecular Weight

409.47

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Shi J, et al. Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation. Drug Metab Dispos. 2016 Apr;44 (4) :554-9.