Biotin-PEG1-azide
Product Specifications
UNSPSC Description
Biotin-PEG1-azide is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Biotin-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Target Antigen
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/biotin-peg1-azide.html
Purity
99.88
Solubility
H2O : 25 mg/mL (ultrasonic)
Smiles
O=C(CCCC[C@@H]1SC[C@@](N2)([H])[C@]1([H])NC2=O)NCCOCCN=[N+]=[N-]
Molecular Weight
356.44
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W096133/Biotin-PEG1-azide-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W096133/Biotin-PEG1-azide-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1204085-48-2
Available Sizes
Curated Selection
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