DBCO-Maleimide
DBCO-Maleimide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. DBCO-Maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
Product Specifications
CAS Number
[1395786-30-7]
UNSPSC
12352203
Hazard Statement
H302, H361, H372, H410
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dbco-maleimide.html
Purity
99.83
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(NCCC(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)=O)CCN4C(C=CC4=O)=O
Molecular Formula
C25H21N3O4
Molecular Weight
427.45
Precautions
H302, H361, H372, H410
References & Citations
[1]Modified antibody and radioactive metal-labelled antibody. WO2019203191A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker
Available Sizes
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