Presenilin 2 loop region Antibody
Our Anti-Presenilin 2 loop region rabbit polyclonal primary antibody detects human and mouse Presenilin 2 loop region, and is IgG. It is validated for use in ICC, WB.
Product Specifications
Product Name Alternative
AD3LP, AD5, E5-1, STM-2
UniProt
P49810
Reactivity
Human, Mouse
Immunogen
A synthetic peptide (KLDPSSQGALQLPYDPEMEEDSYDSFGEP-C) corresponding to human PS1 [306-334] in the loop region conjugated via additional C-terminal Cys to Diphtheria toxoid.
Target
Presenilin 2 loop region
Clonality
Polyclonal
Conjugation
Unconjugated
Dilution
WB: 1:1000; IP: 1:100
Form
Lyophilized
Molecular Weight
22 kDa, 45 kDa (See application details.)
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Full length presenilin 2 (448 aa) has relative MW of about 45 kDa, with this antibody most commonly detected as cleaved CTF of 22 kDa with this antibody. Human or mouse brain samples commonly prepared with reducing agent (50 mM DTT), urea (2.3 M), SDS (1.5%) in 62.5 mM Tris-HCL pH 6.8 sample buffer (without boiling) heating to 50 C for 15 min.
Tested Applications
ICC, WB
Host or Source
Rabbit
Preservative
Lyophilized from PBS, pH 7.4. Contains no preservative.
Isotype
IgG
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