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Presenilin 2 loop region Antibody

Our Anti-Presenilin 2 loop region rabbit polyclonal primary antibody detects human and mouse Presenilin 2 loop region, and is IgG. It is validated for use in ICC, WB.

Product Specifications

Product Name Alternative

AD3LP, AD5, E5-1, STM-2

UniProt

P49810

Reactivity

Human, Mouse

Immunogen

A synthetic peptide (KLDPSSQGALQLPYDPEMEEDSYDSFGEP-C) corresponding to human PS1 [306-334] in the loop region conjugated via additional C-terminal Cys to Diphtheria toxoid.

Target

Presenilin 2 loop region

Clonality

Polyclonal

Conjugation

Unconjugated

Dilution

WB: 1:1000; IP: 1:100

Form

Lyophilized

Molecular Weight

22 kDa, 45 kDa (See application details.)

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

Full length presenilin 2 (448 aa) has relative MW of about 45 kDa, with this antibody most commonly detected as cleaved CTF of 22 kDa with this antibody. Human or mouse brain samples commonly prepared with reducing agent (50 mM DTT), urea (2.3 M), SDS (1.5%) in 62.5 mM Tris-HCL pH 6.8 sample buffer (without boiling) heating to 50 C for 15 min.

Tested Applications

ICC, WB

Host or Source

Rabbit

Preservative

Lyophilized from PBS, pH 7.4. Contains no preservative.

Isotype

IgG

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