Presenilin 1 loop region Antibody
Our Anti-Presenilin 1 loop region rabbit polyclonal primary antibody detects human and mouse Presenilin 1 loop region, and is IgG. It is validated for use in WB.
Product Specifications
Product Name Alternative
Presenilin 1; PS-1; Protein S182; PS1-CTF12; PSEN1; AD3; PS1; PSNL1
UniProt
P49768
Reactivity
Human, Mouse
Immunogen
A synthetic peptide (GDPEAQRRVSKNSKYNA-C) corresponding to human PS1 [301-317] in the loop region conjugated via additional C-terminal Cys to Diphtheria toxoid.
Target
Presenilin 1 loop region
Clonality
Polyclonal
Conjugation
Unconjugated
Dilution
WB: 1:1000
Form
Lyophilized
Molecular Weight
19 kDa, 45 kDa (See application details.)
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Full length presenilin 1 (467 aa) has relative MW of about 45 kDa, with this antibody most commonly detected as cleaved CTF of 19 kDa. Human or mouse brain samples commonly prepared with reducing agent (50mM DTT), urea (2.3 M), SDS (1.5%) in 62.5 mM Tris-HCL pH 6.8 sample buffer (without boiling) heating to 50 C for 15 min.
Tested Applications
WB
Host or Source
Rabbit
Preservative
Lyophilized from PBS, pH 7.4. Contains no preservative.
Isotype
IgG
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