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Presenilin 1 (PS-1) Antibody

Our Anti-Presenilin 1 (PS-1) rabbit polyclonal primary antibody detects human and mouse Presenilin 1 (PS-1), and is IgG. It is validated for use in WB.

Product Specifications

Product Name Alternative

Presenilin 1; PS-1; Protein S182; PS1-CTF12; PSEN1; AD3; PS1; PSNL1

UniProt

P49768

Reactivity

Human, Mouse

Immunogen

A synthetic peptide corresponding to a region (1-20 aa) from the N-terminus of human Presenilin 1 conjugated to Diptheria toxoid.

Target

Presenilin 1 (PS-1)

Clonality

Polyclonal

Conjugation

Unconjugated

Dilution

WB: 1:2000; IHC: 1:100; ICC: 1:100

Form

Lyophilized

Molecular Weight

29 kDa, 45 kDa (see application details)

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

On SDS-PAGE, the predominant form detected by this antibody is the N-terminal Presenilin 1 fragment of approx 29 kDa. The uncleaved form of Presenilin 1 migrates to approx 45 kDa. Human and mouse brain samples commonly prepared with reducing agent (50 mM DTT), urea (2.3M), SDS (1%) in 62.5 mM Tris-HCl pH 6.8 sample buffer heated to 50 C for 15 min. The suggested dilution for IF is 1:100 for acetone or paraformaldehyde fixed cells or tissue.

Tested Applications

IF, WB

Host or Source

Rabbit

Preservative

Lyophilized from PBS, pH 7.4. Contains no preservative.

Isotype

IgG

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