2'-Deoxyguanosine (Standard)

2'-Deoxyguanosine (Standard) is the analytical standard of 2'-Deoxyguanosine. This product is intended for research and analytical applications. 2’-Deoxyguanosine (Deoxyguanosine) is a purine nucleoside with a variety of biological activities. 2’-Deoxyguanosine can induce DNA division in mouse thymus cells. 2’-Deoxyguanosine is a potent cell division inhibitor in plant cells[1][2][3]. In Vitro: 2'-Deoxyguanosine inhibits the clonal growth of HL-60 and K562 leukemia cells with IC50 values of 50 and 80 μM, respectively[1].

Product Specifications

CAS Number

[961-07-9]

Product Name Alternative

Deoxyguanosine (Standard) ; Guanine deoxyriboside (Standard)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Reference Standards

Type

Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2-deoxyguanosine-standard.html

Purity

99.21

Smiles

OC[C@@H](O[C@H](C1)N2C3=C(N=C2)C(NC(N)=N3)=O)[C@H]1O

Molecular Formula

C10H13N5O4

Molecular Weight

267.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Ross DD, et al. Effects of deoxynucleosides on cultured human leukemia cell growth and deoxynucleotide pools. Cancer Res. 1981 Nov;41 (11 Pt 1) :4493-8.|[2]Kizaki H, et al. Adenosine, deoxyadenosine, and deoxyguanosine induce DNA cleavage in mouse thymocytes. J Immunol. 1988 Sep 1;141 (5) :1652-7.|[3]Brulfert A, et al. Deoxyguanosine, a potent cytokinesis inhibitor in plant cells. Experientia. 1974 Sep 15;30 (9) :1010-1.