Thalidezine

Thalidezine is a novel activator of AMP-activated protein kinase (AMPK) . Thalidezine can eliminate anti-apoptotic cancer cells through energy-mediated autophagy death. Thalidezine can be used to study apoptosis intervention [1].

Product Specifications

CAS Number

[18251-36-0]

UNSPSC

12352005

Target

AMPK; Apoptosis

Type

Natural Products

Related Pathways

Apoptosis; Epigenetics; PI3K/Akt/mTOR

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thalidezine.html

Solubility

10 mM in DMSO

Smiles

COC1=C(O2)C3=C(CCN(C)[C@@]3([H])CC4=CC=C(OC)C(OC5=CC=C(C=C5)C[C@@]6([H])C7=C(CCN6C)C=C(OC)C2=C7)=C4)C(O)=C1OC

Molecular Formula

C38H42N2O7

Molecular Weight

638.75

References & Citations

[1]Law BYK, et al. Thalidezine, a novel AMPK activator, eliminates apoptosis-resistant cancer cells through energy-mediated autophagic cell death. Oncotarget. 2017 May 2;8 (18) :30077-30091.