Thalidezine
Thalidezine is a novel activator of AMP-activated protein kinase (AMPK) . Thalidezine can eliminate anti-apoptotic cancer cells through energy-mediated autophagy death. Thalidezine can be used to study apoptosis intervention [1].
Product Specifications
CAS Number
18251-36-0
UNSPSC
12352005
Target
AMPK; Apoptosis
Type
Natural Products
Related Pathways
Apoptosis; Epigenetics; PI3K/Akt/mTOR
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidezine.html
Solubility
10 mM in DMSO
Smiles
COC1=C(O2)C3=C(CCN(C)[C@@]3([H])CC4=CC=C(OC)C(OC5=CC=C(C=C5)C[C@@]6([H])C7=C(CCN6C)C=C(OC)C2=C7)=C4)C(O)=C1OC
Molecular Formula
C38H42N2O7
Molecular Weight
638.75
References & Citations
[1]Law BYK, et al. Thalidezine, a novel AMPK activator, eliminates apoptosis-resistant cancer cells through energy-mediated autophagic cell death. Oncotarget. 2017 May 2;8 (18) :30077-30091.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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