C2 Ceramide

C2 Ceramide (Ceramide 2) is the main lipid of the stratum corneum and a protein phosphatase 1 (PP1) activator. C2 Ceramide activates PP2A and ceramide-activated protein phosphatase (CAPP) . C2 Ceramide induces cells differentiation, autophagy and apoptosis, inhibits mitochondrial respiratory chain complex III. C2 Ceramide is also a skin conditioning agent that protects the epidermal barrier from water loss[1][2][3][4][5].

Product Specifications

CAS Number

[3102-57-6]

Product Name Alternative

Ceramide 2

UNSPSC

12352211

Target

Apoptosis; Autophagy; Mitochondrial Metabolism; Phosphatase

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Endocrinology; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/c2-ceramide.html

Purity

99.85

Solubility

DMSO : 50 mg/mL (ultrasonic) |Ethanol : 25 mg/mL (ultrasonic; warming)

Smiles

O[C@H](/C=C/CCCCCCCCCCCCC)[C@H](CO)NC(C)=O

Molecular Formula

C20H39NO3

Molecular Weight

341.53

References & Citations

[1]P A Hill, et al. Ceramide-induced Cell Death/Survival in Murine Osteoblasts. J Endocrinol. 2010 Aug;206 (2) :225-33.|[2]Ji-Youn Kim, et al. Role of Protein Phosphatase 1 in Angiogenesis and Odontoblastic Differentiation of Human Dental Pulp Cells. J Endod. 2017 Mar;43 (3) :417-424.|[3]R T Dobrowsky, et al. Ceramide Stimulates a Cytosolic Protein Phosphatase. J Biol Chem. 1992 Mar 15;267 (8) :5048-51.|[4]R T Dobrowsky, et al. Ceramide Activates Heterotrimeric Protein Phosphatase 2A. J Biol Chem. 1993 Jul 25;268 (21) :15523-30.|[5] Maria Bernadete Riemma Pierre, et al. Influence of ceramide 2 on in vitro skin permeation and retention of 5-ALA and its ester derivatives, for Photodynamic Therapy. Brazilian Journal of Pharmaceutical Sciences. 2009, 45 (1), 109-116.|[6]Wenyuan Zhu, et al. C2-ceramide induces cell death and protective autophagy in head and neck squamous cell carcinoma cells. Int J Mol Sci. 2014 Feb 21;15 (2) :3336-55.