Heptamidine (dimethanesulfonate)

Heptamidine dimethanesulfonate (SBi4211 dimethanesulfonate) is a potent Pentamidine-related inhibitor of the calcium-binding protein S100B (Kd=6.9 μM), selectively kills melanoma cells with S100B over those without S100B[1]. Heptamidine is a useful tool for the investigation of Myotonic dystrophy (DM) [2].

Product Specifications

CAS Number

[161374-55-6]

Product Name Alternative

SBi4211 (dimethanesulfonate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/heptamidine-dimethanesulfonate.html

Purity

99.82

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

N=C(C1=CC=C(OCCCCCCCOC2=CC=C(C(N)=N)C=C2)C=C1)N.CS(=O)(O)=O.CS(=O)(O)=O

Molecular Formula

C23H36N4O8S2

Molecular Weight

560.68

Precautions

H302, H315, H319, H335

References & Citations

[1]McKnight LE, et al. Structure-Based Discovery of a Novel Pentamidine-Related Inhibitor of the Calcium-Binding Protein S100B. ACS Med Chem Lett. 2012 Dec 13;3 (12) :975-979. Epub 2012 Sep 25.|[2]Coonrod LA, et al. Reducing levels of toxic RNA with small molecules.ACS Chem Biol. 2013 Nov 15;8 (11) :2528-37.