Conivaptan (hydrochloride)
Conivaptan (hydrochloride) is a non-peptide antagonist of vasopressin receptor, with Ki values of 0.48 and 3.04 nM for rat liver V1A receptor and rat kidney V2 receptor respectively.
Product Specifications
CAS Number
168626-94-6
Product Name Alternative
YM 087
UNSPSC
12352005
Hazard Statement
H361
Target
Vasopressin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Conivaptan-hydrochloride.html
Purity
99.95
Solubility
DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=CC=C1C2=CC=CC=C2)NC3=CC=C(C(N4CCC(N=C(C)N5)=C5C6=CC=CC=C64)=O)C=C3.Cl
Molecular Formula
C32H27ClN4O2
Molecular Weight
535.04
Precautions
H361
References & Citations
[1]Wada K, et al. Intravenous administration of conivaptan hydrochloride improves cardiac hemodynamics in rats with myocardial infarction-induced congestive heart failure. Eur J Pharmacol. 2005 Jan 10;507 (1-3) :145-51. Epub 2005 Jan 1.|[2]Fernandez-Varo G, et al. Effect of the V1a/V2-AVP receptor antagonist, Conivaptan, on renal water metabolism and systemic hemodynamics in rats with cirrhosis and ascites. J Hepatol. 2003 Jun;38 (6) :755-61.|[3]Yatsu T, et al. Cardiovascular and renal effects of conivaptan hydrochloride (YM087), a vasopressin V1A and V2 receptor antagonist, in dogs with pacing-induced congestive heart failure. Eur J Pharmacol. 1999 Jul 9;376 (3) :239-46.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
V1a Receptor ; V2 Receptor
Citation 01
Biomed J. 2020 Aug;43 (4) :368-374.|Dig Dis Sci. 2022 Aug;67 (8) :3683-3692.|Eur J Pharmacol. 2020 Aug 5;880:173157.|Front Pharmacol. 2019 Nov 15;10:1380.|J Med Chem. 2022 Jul 14;65 (13) :9295-9311.|J Med Chem. 2024 Apr 11;67 (7) :5935-5944.|J Pharm Biomed Anal. 2021 Feb 20:195:113870.|J Transl Med. 2025 Jan 22;23 (1) :103.|Nat Commun. 2025 Nov 4;16 (1) :9734.|Neurogastroenterol Motil. 2019 Feb;31 (2) :e13493.|SSRN. 2023 May 30.|SSRN. 2025 Jun 18.|Biomed Pharmacother. 2025 Jun 20:189:118246.
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