ML 145

ML 145 is a selective and competitive human GPR35/CXCR8 antagonist with an IC50/EC50 of 20.1 nM. ML 145 has over 1000-fold more selective for GPR35 compared to GPR55 (IC50/EC50=21.7 μM) [1]. ML 145 has no significant activity for GPR35 at either rodent ortholog[2].

Product Specifications

CAS Number

[1164500-72-4]

UNSPSC

12352005

Target

CXCR; GPR35

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/ml-145.html

Purity

96.09

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(/C=C(S1)/C(N(CCCC(NC2=CC(O)=C(C(O)=O)C=C2)=O)C1=S)=O)=C\C3=CC=CC=C3

Molecular Formula

C24H22N2O5S2

Molecular Weight

482.57

References & Citations

[1]Heynen-Genel S, et al. Selective GPR35 Antagonists - Probes 1 & 2. National Center for Biotechnology Information (US) ; 2010-2010 Feb 28.|[2]Laura Jenkins, et al. Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J Pharmacol Exp Ther. 2012 Dec;343 (3) :683-95.