(-) -Denudatin B

(-) -Denudatin B is an antiplatelet agent. (-) -Denudatin B relaxed vascular smooth muscle by inhibiting the Ca2+ influx through voltage-gated and receptor-operated Ca2+ channels[1]. And (-) -Denudatin B has nonspecific antiplatelet action

Product Specifications

CAS Number

[87402-88-8]

Product Name Alternative

Denudatin B

UNSPSC

12352005

Target

Calcium Channel

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/minus-denudatin-b.html

Purity

97.88

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CO[C@@]12C(O[C@@](C3=CC(OC)=C(C=C3)OC)([H])[C@H]1C)=CC(C(CC=C)=C2)=O

Molecular Formula

C21H24O5

Molecular Weight

356.41

References & Citations

[1]Yu SM, et al. Vasorelaxing effect in rat thoracic aorta caused by denudatin B, isolated from the Chinese herb, magnolia fargesii. Eur J Pharmacol. 1990;187 (1) :39-47.|[2]Teng CM, et al. Inhibition of thrombin- and collagen-induced phosphoinositides breakdown in rabbit platelets by a PAF antagonist--denudatin B, an isomer of kadsurenone. Thromb Res. 1990;59 (1) :121-130.