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UNC9994

UNC9994, an analog of Aripiprazole, is a functionally selective β-arrestin-biased dopamine D2 receptor (D2R) agonist with EC50 i-regulated cAMP production. Antipsychotic Activity[1].

Product Specifications

CAS Number

1354030-51-5

Product Name Alternative

3M-852A

UNSPSC

12352005

Target

5-HT Receptor; Arrestin; Dopamine Receptor; Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/unc9994.html

Purity

98.06

Solubility

10 mM in DMSO

Smiles

ClC1=CC=CC(C2CCN(CC2)CCCOC3=CC4=C(C=C3)SC=N4)=C1Cl

Molecular Formula

C21H22Cl2N2OS

Molecular Weight

421.38

References & Citations

[1]Allen JA, et al. Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. Proc Natl Acad Sci U S A. 2011;108 (45) :18488-18493.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

D2 Receptor; D3 Receptor; D4 Receptor; H1 Receptor; Histamine Receptor; mLAG-3; α-1 microglobulin

Available Sizes

Frequently Asked Questions

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