Dimetridazole

Dimetridazole is a nitroimidazole antibiotic. Dimetridazole inhibits protein synthesis in cultures of Campylobacter jejuni. Dimetridazole is genotoxic. Dimetridazole can be used in the research of protozoal and bacterial infections[1][2][3][4].

Product Specifications

CAS Number

[551-92-8]

Product Name Alternative

1,2-Dimethyl-5-nitroimidazole

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Antibiotic; Bacterial; Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Dimetridazole.html

Purity

99.80

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=[N+](C1=CN=C(C)N1C)[O-]

Molecular Formula

C5H7N3O2

Molecular Weight

141.13

Precautions

H315, H319, H335

References & Citations

[1]Zaghdoudi M, et al. Direct and indirect electrochemical reduction prior to a biological treatment for dimetridazoleremoval. J Hazard Mater. 2017 Aug 5;335:10-17.|[2]Fernie DS, et al. The effect of the nitroimidazole drug dimetridazole on microaerophilic campylobacters. J Med Microbiol. 1977 May;10 (2) :233-40. |[3]Jokipii L, et al. Comparative evaluation of the 2-methyl-5-nitroimidazole compounds dimetridazole, metronidazole, secnidazole, ornidazole, tinidazole, carnidazole, and panidazole against Bacteroides fragilis and other bacteria of the Bacteroides fragilis group. Antimicrob Agents Chemother. 1985 Oct;28 (4) :561-4.|[4]Ré JL, et al. Evaluation of the genotoxic activity of metronidazole and dimetridazole in human lymphocytes by the comet assay. Mutat Res. 1997 Apr 29;375 (2) :147-55.