2′-Hydroxygenistein

2′-Hydroxygenistein is a natural product that can be isolated from Crotalaria pallida and C. assamica. 2′-Hydroxygenistein shows anti-inflammatory activity. 2′-Hydroxygenistein shows significant concentration-dependent inhibitory effects on the release of β-glucuronidase and lysozyme from rat neutrophils, with IC50 values of 5.9 ± 1.4 and 9.7 ± 3.5 μM, respectively[1].

Product Specifications

CAS Number

[1156-78-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; β-glucuronidase

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/2-hydroxygenistein.html

Purity

99.41

Solubility

10 mM in DMSO

Smiles

O=C1C(C2=CC=C(O)C=C2O)=COC3=CC(O)=CC(O)=C13

Molecular Formula

C15H10O6

Molecular Weight

286.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Ko HH, Weng JR, Tsao LT, Yen MH, Wang JP, Lin CN. Anti-inflammatory flavonoids and pterocarpanoid from Crotalaria pallida and C. assamica. Bioorg Med Chem Lett. 2004 Feb 23;14 (4) :1011-4.