Mebendazole

Mebendazole is a highly effective, broad-spectrum antihelmintic against nematode infestations. Mebendazole also exhibits inhibitory effect against glioblastoma multiforme (GBM), inhibits Hedgehog pathway and tubulin polymerization. Mebendazole is orally active and can cross CNS penetration[1][2][3].

Product Specifications

CAS Number

[31431-39-7]

UNSPSC

12352005

Hazard Statement

H302, H350, H360

Target

Apoptosis; Microtubule/Tubulin; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/Mebendazole.html

Purity

99.88

Solubility

DMSO : 4.17 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)

Smiles

O=C(OC)NC1=NC2=CC=C(C(C3=CC=CC=C3)=O)C=C2N1

Molecular Formula

C16H13N3O3

Molecular Weight

295.29

Precautions

H302, H350, H360

References & Citations

[1]Bai RY, et al. Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme. Neuro Oncol. 2011 Sep;13 (9) :974-82. |[2]Larsen AR, et al. Repurposing the antihelmintic mebendazole as a hedgehog inhibitor. Mol Cancer Ther. 2015 Jan;14 (1) :3-13. |[3]Erdinçler P, et al. The role of mebendazole in the surgical treatment of central nervous system hydatid disease. Br J Neurosurg. 1997 Apr;11 (2) :116-20.