CA77.1
CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics. CA77.1 is a derivative of AR7 and can increase the expression of the lysosomal receptor LAMP2A in lysosomes. CA77.1 improves behavior and neuropathology in PS19 mice model and can be used for alzheimer's disease research[1].
Product Specifications
CAS Number
2412270-22-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Autophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ca77-1.html
Concentration
10mM
Purity
99.98
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : < 1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(NC1=CC=C(C2=NC3=CC=C(Cl)C=C3N=C2)C=C1)=O
Molecular Formula
C16H12ClN3O
Molecular Weight
297.74
Precautions
H302, H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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