JW 642
Product Specifications
UNSPSC Description
JW 642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively.
IC50 value: 7.6/14/3.7 nM(mouse/rat/human MAGL) [1]
Target: MAGL inhibitor
JW 642 is selective for MAGL, requiring much higher concentrations to effectively inhibit fatty acid amide hydrolase activity (IC50s = 31, 14, and 20.6 μM for mouse, rat, and human brain membranes, respectively).
Target Antigen
MAGL
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/JW-642.html
Purity
99.90
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(OC(C(F)(F)F)C(F)(F)F)N(CC1)CCN1CC2=CC(OC3=CC=CC=C3)=CC=C2
Molecular Weight
462.39
References & Citations
[1]Chang JW, et al. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem Biol. 2012 May 25;19(5):579-88.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12332/JW-642-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12332/JW-642-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1416133-89-5
Available Sizes
Curated Selection
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