Retro-2

Retro-2 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an ebolavirus (EBOV) infection inhibitor with an EC50 of 12.2 μM in HeLa cells. Retro-2 induces cell autophagy[1][2][3].

Product Specifications

CAS Number

[1201652-50-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Filovirus; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/retro-2.html

Purity

98.0

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=CC=C1)C2=CC=CC=C2/N=C/C3=CC=C(C)S3

Molecular Formula

C19H16N2OS

Molecular Weight

320.41

Precautions

H302, H315, H319, H335

References & Citations

[1] Bahne Stechmann, et al. Inhibition of retrograde transport protects mice from lethal ricin challenge. Cell. 2010 Apr 16;141 (2) :231-42.|[2]Valérie Nicolas, et al. Small Trafficking Inhibitor Retro-2 Disrupts the Microtubule-Dependent Trafficking of Autophagic Vacuoles. Front Cell Dev Biol. 2020 Jun 18;8:464.|[3]Olena Shtanko, et al. Retro-2 and its dihydroquinazolinone derivatives inhibit filovirus infection. Antiviral Res. 2018 Jan;149:154-163.