Dolasetron (Mesylate hydrate)

Dolasetron Mesylate hydrate (MDL-73147EF hydrate) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.

Product Specifications

CAS Number

[878143-33-0]

Product Name Alternative

MDL-73147EF (hydrate)

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Dalasetron-Mesylate-hydrate.html

Purity

99.88

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(C1=CNC2=C1C=CC=C2)O[C@@H]3C[C@@](CC4C5)([H])[N@](CC4=O)[C@@]5([H])C3.O=S(C)(O)=O.O

Molecular Formula

C20H26N2O7S

Molecular Weight

438.49

Precautions

H302, H312, H332

References & Citations

[1]Faria C, et al. Outcomes Associated with 5-HT3-RA Therapy Selection in Patients with Chemotherapy-Induced Nausea and Vomiting: A Retrospective Claims Analysis. Am Health Drug Benefits. 2014 Jan;7 (1) :50-8.|[2]Schwartzberg L, et al. Pooled analysis of phase III clinical studies of palonosetron versus ondansetron, dolasetron, and granisetron in the prevention of chemotherapy-induced nausea and vomiting (CINV) . Support Care Cancer. 2014 Feb;22 (2) :469-77.