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N-Nitrosodiethylamine (Standard)

N-Nitrosodiethylamine (Standard) is the analytical standard of N-Nitrosodiethylamine. This product is intended for research and analytical applications. N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

Product Specifications

CAS Number

55-18-5

Product Name Alternative

Diethylnitrosamine (Standard) ; DEN (Standard) ; DENA (Standard)

UNSPSC

12352211

Hazard Statement

H227-H301-H340-H350-H402-H412

Target

DNA/RNA Synthesis; Reference Standards

Type

Reference Standards

Related Pathways

Cell Cycle/DNA Damage; Others

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-nitrosodiethylamine-standard.html

Smiles

CCN(CC)N=O

Molecular Formula

C4H10N2O

Molecular Weight

102.14

Precautions

P210-P264-P270-P273-P280-P330-P370+P378-P403-P405-P501

References & Citations

[1]Ramakrishnan G, et al. Suppression of N-nitrosodiethylamine induced hepatocarcinogenesis by silymarin in rats. Chem Biol Interact. 2006 Jun 10;161 (2) :104-14. |[2]Bansal AK, et al. Protective role of Vitamin E pre-treatment on N-nitrosodiethylamine induced oxidative stress in rat liver. Chem Biol Interact. 2005 Oct 20;156 (2-3) :101-11. |[3]Gombar CT, et al. Pharmacokinetics of N-nitrosodimethylamine in beagles. Cancer Res. 1987 Jan 15;47 (2) :343-7.|[4]Verna L, et al. N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation. Pharmacol Ther. 1996;71 (1-2) :57-81.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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