PKM2 activator 5

PKM2 activator 5 (compound 8) is a PKM2 activator with an AC50 value of 0.316 µM. PKM2 activator 5 has the potential to alter the aberrant metabolism of cancer cells[1].

Product Specifications

CAS Number

[796092-26-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Pyruvate Kinase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pkm2-activator-5.html

Purity

96.24

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=S(N1CCN(S(=O)(C2=CC=C(OCCO3)C3=C2)=O)CC1)(C4=CC=CC(F)=C4)=O

Molecular Formula

C18H19FN2O6S2

Molecular Weight

442.48

Precautions

H302, H315, H319

References & Citations

[1]Boxer MB, et al. Evaluation of substituted N, N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. J Med Chem. 2010 Feb 11;53 (3) :1048-55.