PKM2 activator 5
PKM2 activator 5 (compound 8) is a PKM2 activator with an AC50 value of 0.316 µM. PKM2 activator 5 has the potential to alter the aberrant metabolism of cancer cells[1].
Product Specifications
CAS Number
[796092-26-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Pyruvate Kinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pkm2-activator-5.html
Purity
96.24
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=S(N1CCN(S(=O)(C2=CC=C(OCCO3)C3=C2)=O)CC1)(C4=CC=CC(F)=C4)=O
Molecular Formula
C18H19FN2O6S2
Molecular Weight
442.48
Precautions
H302, H315, H319
References & Citations
[1]Boxer MB, et al. Evaluation of substituted N, N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. J Med Chem. 2010 Feb 11;53 (3) :1048-55.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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