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MN-64

MN-64 is a potent tankyrase 1 inhibitor, with IC50s of 6 nM, 72 nM, 19.1 μM, and 39.4 μM for TNKS1, TNKS2, ARTD1 and ARTD2, respectively.

Product Specifications

CAS Number

92831-11-3

UNSPSC

12352005

Hazard Statement

H301

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/MN-64.html

Purity

99.61

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C=C(C2=CC=C(C(C)C)C=C2)OC3=CC=CC=C13

Molecular Formula

C18H16O2

Molecular Weight

264.32

Precautions

H301

References & Citations

[1]Narwal M, et al. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem. 2013 Oct 24;56 (20) :7880-9.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PARP1; PARP2; TNKS1/PARP5A; TNKS2/PARP5B

Available Sizes

Frequently Asked Questions

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