ITSA-1
ITSA-1 is an activator of histone deacetylase (HDAC), and counteract trichostatin A (TSA) -induced cell cycle arrest, histone acetylation, and transcriptional activation[1].
Product Specifications
CAS Number
200626-61-5
UNSPSC
12352005
Hazard Statement
H302
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ITSA-1.html
Purity
99.73
Solubility
DMSO : ≥ 32 mg/mL
Smiles
O=C(N1N=NC2=CC=CC=C21)C3=CC=C(Cl)C=C3Cl
Molecular Formula
C13H7Cl2N3O
Molecular Weight
292.12
Precautions
H302
References & Citations
[1]Koeller KM et al. Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histoneand tubulin acetylation. Chem Biol. 2003 May;10 (5) :397-410.|[2]Behera J, et al. Hydrogen Sulfide Promotes Bone Homeostasis by Balancing Inflammatory Cytokine Signaling in CBS-Deficient Mice through an Epigenetic Mechanism. Sci Rep. 2018 Oct 15;8 (1) :15226.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC
Available Sizes
Frequently Asked Questions
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