BI-4394

BI-4394 (MMP13-IN-3), a chemical probe, is a potent, selective, and orally active MMP-13 inhibitor (IC50=1 nM[1]) for the potential treatment of osteoarthritis[2]. BI-4394 is >1000 selective over other MMPs[1].

Product Specifications

CAS Number

[1222173-37-6]

Product Name Alternative

MMP13-IN-3

UNSPSC

12352005

Target

MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/bi-4394.html

Purity

99.09

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C(N1)=CC2=C1C=CC(C3=CC(C(NCC4=CC=C(C(O)=O)C=C4)=O)=NN3C)=C2)OCC

Molecular Formula

C24H22N4O5

Molecular Weight

446.46

References & Citations

[1]Taylor SJ, et al. Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13. J Med Chem. 2011 Dec 8;54 (23) :8174-87.|[2]Ruminski PG, et al. Discovery of N- (4-Fluoro-3-methoxybenzyl) -6- (2- (((2S,5R) -5- (hydroxymethyl) -1,4-dioxan-2-yl) methyl) -2H-tetrazol-5-yl) -2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis. J Med Chem. 2016 Jan 14;59 (1) :313-27.