Fagomine
Fagomine is a mild glycosidase inhibitor. The Ki of the iminosugar Fagomine is 4.8 μM, 39 μM, and 70 μM for Amyloglucosidase (A.niger), β-Glucosidase (bovine), and Isomaltase (yeast), respectively.
Product Specifications
CAS Number
[53185-12-9]
Product Name Alternative
D-Fagomine
UNSPSC
12352005
Target
Glycosidase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Fagomine.html
Purity
98.97
Solubility
H2O : ≥ 36 mg/mL
Smiles
O[C@@H]1CCN[C@@H]([C@H]1O)CO
Molecular Formula
C6H13NO3
Molecular Weight
147.17
References & Citations
[1]Mena-Barragán T, et al. Inhibitor versus chaperone behaviour of d-fagomine, DAB and LAB sp2-iminosugar conjugates againstglycosidases: A structure-activity relationship study in Gaucher fibroblasts. Eur J Med Chem. 2015 Aug 31. pii: S0223-5234 (15) 30222-1.|[2]Ramos-Romero S, et al. Effect of (D) -fagomine on excreted Enterobacteria and weight gain in rats fed a high-fat high-sucrose diet. Obesity (Silver Spring) . 2014 Apr;22 (4) :976-9.|[3]Molinar-Toribio E, et al. D-Fagomine attenuates metabolic alterations induced by a high-energy-dense diet in rats. Food Funct. 2015 Aug;6 (8) :2614-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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