YK-2-69

YK-2-69 is a highly selective DYRK2 inhibitor with an IC50 value of 9 nM. YK-2-69 specifically interacts with Lys-231 and Lys-234 of DYRK2 and can be utilized in researches related to prostate cancer[1].

Product Specifications

CAS Number

[2619846-89-6]

UNSPSC

12352005

Target

DYRK

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/yk-2-69.html

Purity

99.57

Solubility

DMSO : 5.83 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N1CCN(CC1)CC)C2=CN=C(NC3=NC(C4=CC5=C(N=C(N(C)C)S5)C=C4)=C(F)C=N3)C=C2

Molecular Formula

C25H27FN8OS

Molecular Weight

506.60

References & Citations

[1]Yuan K, et al. Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer. Nat Commun. 2022 May 25;13 (1) :2903.