L-Cysteinesulfinic acid

L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively[1].

Product Specifications

CAS Number

[1115-65-7]

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Endogenous Metabolite; mGluR

Type

Natural Products

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/L-Cysteinesulfinic_acid.html

Purity

99.98

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

N[C@@H](CS(O)=O)C(O)=O

Molecular Formula

C3H7NO4S

Molecular Weight

153.16

Precautions

H315, H319, H335

References & Citations

[1]Shi Q, et al. L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists. J Pharmacol Exp Ther. 2003 Apr;305 (1) :131-42.|[2]Boss V, et al. L-cysteine sulfinic acid as an endogenous agonist of a novel metabotropic receptor coupled to stimulation of phospholipase D activity.