AVE1231
Product Specifications
Product Name Alternative
A293
UNSPSC Description
AVE1231 (A293) is a dual-pore potassium channel TASK-1 inhibitor. AVE1231 blocks carbamoylcholine chloride (HY-B1208)-activated IKACh (IC50=8.4 μM). AVE1231 can be used in the study of arrhythmias and atrial fibrillation[1][2].
Target Antigen
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ave1231.html
Purity
98.61
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](C1=CC=C(OC)N=C1)CC)C2=CC=CC=C2NS(=O)(CCCC)=O
Molecular Weight
405.51
References & Citations
[1]Wiedmann F, et al. Identification of the A293 (AVE1231) binding site in the cardiac two-pore-domain potassium channel TASK-1: a common low affinity antiarrhythmic drug binding site[J]. Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2019, 52(5).|[2]Wirth K J, et al. In vitro and in vivo effects of the atrial selective antiarrhythmic compound AVE1231[J]. Journal of cardiovascular pharmacology, 2007, 49(4): 197-206.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-126486/AVE1231-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-126486/AVE1231-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
767334-89-4
Available Sizes
Curated Selection
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