GK921
GK921 is a transglutaminase 2 (TGase) inhibitor with an IC50 of 7.71 μM for human recombinant TGase 2.
Product Specifications
CAS Number
[1025015-40-0]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Glutaminase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GK921.html
Purity
99.91
Solubility
DMSO : ≥ 30 mg/mL
Smiles
C12=NC=CC=C1N=C(OCCN3CCCC3)C(C#CC4=CC=CC=C4)=N2
Molecular Formula
C21H20N4O
Molecular Weight
344.41
Precautions
H315, H319, H320
References & Citations
[1]Ku BM, et al. Transglutaminase 2 inhibitor abrogates renal cell carcinoma in xenograft models. J Cancer Res Clin Oncol. 2014 May;140 (5) :757-67.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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